General Information

    • DRAMP ID

    • DRAMP03034

    • Peptide Name

    • Mastoparan-like peptide 12b (Insects, animals)

    • Source

    • Vespa magnifica (Hornet)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • INWKGIAAMKKLL

    • Sequence Length

    • 13

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • [Ref.16330062]Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=15 µg/ml);
      • Gram-positive bacteria: Staphylococcus aureus ATCC 2592 (MIC=3.7 µg/ml);
      • Fungi: Candida albicans ATCC 2002 (MIC=7.5 µg/ml).

    • Hemolytic Activity

      • [Ref.16330062]Little hemolytic activity at 50 μg/ml against rabbit red blood cells

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03034 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C70H120N18O15S

    • Absent Amino Acids

    • CDEFHPQRSTVY

    • Common Amino Acids

    • K

    • Mass

    • 1485.89

    • PI

    • 10.3

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +3

    • Boman Index

    • 5.63

    • Hydrophobicity

    • 0.431

    • Aliphatic Index

    • 135.38

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 458.33

    • Polar Residues

    • 2

DRAMP03034

Comments Information

    • Function

    • Mast cell degranulating peptide. Has little hemolytic activity. Shows antimicrobial activity.

    • Tissue specificity

    • Expressed by the venom gland.

    • PTM

    • C-terminal amidation (Leucine amide

Literature Information

  • ·Literature 1

    • Title

    • Two families of antimicrobial peptides from wasp (Vespa magnifica) venomThe mastoparanogen from wasp.

    • Reference

    • Toxicon. 2006 Feb;47(2):249-53. Epub 2005 Dec 5. Peptides. 2006 Dec;27(12):3053-7. Epub 2006 Oct 13.

    • Author

    • Xu X, Li J, Lu Q, Yang H, Zhang Y, Lai R.Xu X, Yang H, Yu H, Li J, Lai R.