General Information

    • DRAMP ID

    • DRAMP03036

    • Peptide Name

    • Mastoparan-like peptide 12d (Insects, animals)

    • Source

    • Vespa magnifica (Hornet)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • INLKAIAAMAKKLL

    • Sequence Length

    • 14

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=3.0 µg/ml);
      • Gram-positive bacteria: Staphylococcus aureus ATCC 2592 (MIC=1.5 µg/ml).
      • Fungi: Candida albicans ATCC 2002 (MIC=12.0 µg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03036 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03036.

Physicochemical Information

    • Formula

    • C69H128N18O16S

    • Absent Amino Acids

    • CDEFGHPQRSTVWY

    • Common Amino Acids

    • A

    • Mass

    • 1497.95

    • PI

    • 10.3

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +3

    • Boman Index

    • 10.9

    • Hydrophobicity

    • 1.021

    • Aliphatic Index

    • 167.86

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 1

DRAMP03036

Comments Information

    • Function

    • Shows mast cell degranulation and antimicrobial activities.

    • Tissue specificity

    • Expressed by the venom gland.

    • PTM

    • C-terminal amidation (Leucine amide

Literature Information

  • ·Literature 1

    • Title

    • The mastoparanogen from wasp.

    • Reference

    • Peptides. 2006 Dec;27(12):3053-3057.

    • Author

    • Xu X, Yang H, Yu H, Li J, Lai R.