General Information

    • DRAMP ID

    • DRAMP03044

    • Peptide Name

    • Protonectin (Agelaia-chemotactic peptide, Agelaia-CP; Insects, animals)

    • Source

    • Agelaia pallipes pallipes (Neotropical social wasp)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • ILGTILGLLKGL

    • Sequence Length

    • 12

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.15225564]Gram-negative bacteria: Escherichia coli (MIC=25 µg/ml), Pseudomonas aeruginosa (MIC=1.7 µg/ml);
      • Gram-positive bacteria: Bacillus subtilis (MIC=3.1 µg/ml), Staphylococcus aureus (MIC=12.5 µg/ml).

    • Hemolytic Activity

      • [Ref.15052574]Non-hemolytic activity against rat red blood cell

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03044 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C58H107N13O14

    • Absent Amino Acids

    • ACDEFHMNPQRSVWY

    • Common Amino Acids

    • L

    • Mass

    • 1210.57

    • PI

    • 8.75

    • Basic Residues

    • 1

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +1

    • Boman Index

    • 29.14

    • Hydrophobicity

    • 1.85

    • Aliphatic Index

    • 227.5

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 4

DRAMP03044

Comments Information

    • Function

    • Mast cell degranulator that induces a potent chemotaxis in polymorphonucleated leukocyte (PMNL) cells. Shows potent antimicrobial action against both Gram-positive and Gram-negative bacteria. Shows no hemolytic activity.

Literature Information

  • ·Literature 1

    • Title

    • Structural and biological characterization of two novel peptides from the venom of the neotropical social wasp Agelaia pallipes pallipes.

    • Reference

    • Toxicon. 2004 Jul;44(1):67-74.

    • Author

    • Mendes MA, de Souza BM, Marques MR, Palma MS.
  • ·Literature 2

    • Title

    • Structural characterization of novel chemotactic and mastoparan peptides from the venom of the social wasp Agelaiapallipes pallipes by high-performance liquid chromatography/electrospray ionization tandem mass spectrometry.

    • Reference

    • Rapid Commun Mass Spectrom. 2004;18(6):636-642.

    • Author

    • Mendes MA, Monson de Souza B, Delazari dos Santos L, Palma MS.