General Information

    • DRAMP ID

    • DRAMP03047

    • Peptide Name

    • Venom peptide 2-long (OdVP2L; analog of OdVP2; Insects, animals)

    • Source

    • Orancistrocerus drewseni (Solitary wasp)

    • Family

    • Belongs to the MCD family (Protonectin subfamily)

    • Gene

    • VP2

    • Sequence

    • EPILGIITSLLKSL

    • Sequence Length

    • 14

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • [Swiss_Prot Entry P86147]Fungi: Botrytis cinerea (MIC=0.5 µg/ml), Candida albicans (MIC=100 µg/ml);
      • Gram-positive bacterium: S. aureus (MIC=25 µg/ml);
      • Gram-negative bacterium: Escherichia coli.

    • Hemolytic Activity

      • [Swiss_Prot Entry P86147]has potent hemolytic activity against ovine erythrocytes at micromolar concentrations

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03047 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03047.

Physicochemical Information

    • Formula

    • C70H125N15O20

    • Absent Amino Acids

    • ACDFHMNQRVWY

    • Common Amino Acids

    • L

    • Mass

    • 1496.85

    • PI

    • 6.1

    • Basic Residues

    • 1

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 7

    • Net Charge

    • 0

    • Boman Index

    • 13.65

    • Hydrophobicity

    • 1.214

    • Aliphatic Index

    • 195

    • Half Life

      • Mammalian:1 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 4

DRAMP03047

Comments Information

    • Function

    • Has potent hemolytic activity against ovine erythrocytes at micromolar concentrations.

    • Tissue specificity

    • Expressed by the venom gland.

Literature Information

  • ·Literature 1

    • Title

    • Isolation and molecular cloning of venom peptides from Orancistrocerus drewseni (Hymenoptera: Eumenidae).

    • Reference

    • Toxicon. 2010 Apr 1;55(4):711-718.

    • Author

    • Baek JH, Lee SH.
  • ·Literature 2

    • Title

    • Novel mastoparan and protonectin analogs isolated from a solitary wasp, Orancistrocerus drewseni drewseni.

    • Reference

    • Amino Acids. 2009 Jul;37(2):389-394.

    • Author

    • Murata K, Shinada T, Ohfune Y, Hisada M, Yasuda A, Naoki H, Nakajima T.