General Information

    • DRAMP ID

    • DRAMP03050

    • Peptide Name

    • Dominulin-A (Insects, animals)

    • Source

    • Polistes dominulus (European paper wasp)

    • Family

    • Belongs to the MCD family (Mastoparan subfamily)

    • Gene

    • Not found

    • Sequence

    • INWKKIAEVGGKILSSL

    • Sequence Length

    • 17

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-positive bacterium: Bacillus subtilis ATCC 6633 (MIC=2 µg/ml);
      • Gram-negative bacterium: Escherichia coli JM109 (MIC=8 µg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03050 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C86H146N22O23

    • Absent Amino Acids

    • CDFHMPQRTY

    • Common Amino Acids

    • IK

    • Mass

    • 1856.24

    • PI

    • 9.7

    • Basic Residues

    • 3

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +2

    • Boman Index

    • -2.24

    • Hydrophobicity

    • 0.3

    • Aliphatic Index

    • 137.65

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 343.75

    • Polar Residues

    • 5

DRAMP03050

Comments Information

    • Function

    • Shows antimicrobial activity.

Literature Information

  • ·Literature 1

    • Title

    • Dominulin A and B: two new antibacterial peptides identified on the cuticle and in the venom of the social paper wasp Polistes dominulus using MALDI-TOF, MALDI-TOF/TOF, and ESI-ion trap.

    • Reference

    • J Am Soc Mass Spectrom. 2006 Mar;17(3):376-383.

    • Author

    • Turillazzi S, Mastrobuoni G, Dani FR, Moneti G, Pieraccini G, la Marca G, Bartolucci G, Perito B, Lambardi D, Cavallini V, Dapporto L.