General Information

    • DRAMP ID

    • DRAMP03052

    • Peptide Name

    • PP13 (Insects, animals)

    • Source

    • Pteromalus puparum (wasp)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GAARKSIRLHRLYTWKATIYTR

    • Sequence Length

    • 22

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus CVCC1882 (MIC=23.3 µM), Sarcina lutea CVCC1600 (MIC=8 µM), Bacillus pumilus CVCC709 (MIC=9 µM), Bacillus subtilis CVCC717 (MIC=13.3 µM).
      • Gram-positive bacterium: Escherichia coli CVCC1570 (MIC=16.7 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Cell membrane

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Alpha helix (CD)

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03052 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03052.

Physicochemical Information

    • Formula

    • C121H197N39O29

    • Absent Amino Acids

    • CDEFMNPQV

    • Common Amino Acids

    • R

    • Mass

    • 2662.14

    • PI

    • 11.58

    • Basic Residues

    • 7

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +7

    • Boman Index

    • -58.45

    • Hydrophobicity

    • -0.627

    • Aliphatic Index

    • 84.55

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 8480

    • Absorbance 280nm

    • 403.81

    • Polar Residues

    • 7

DRAMP03052

DRAMP03052 chydropathy plot

Comments Information

    • Function

    • These peptides have net positive charges and are active against both Gram-negative and -positive bacteria, but are not active against fungi tested.

Literature Information

  • ·Literature 1

    • Title

    • Novel antimicrobial peptides identified from an endoparasitic wasp cDNA library.

    • Reference

    • J Pept Sci. 2010 Jan;16(1):58-64.

    • Author

    • Shen X, Ye G, Cheng X, Yu C, Yao H, Hu C.