General Information

    • DRAMP ID

    • DRAMP03056

    • Peptide Name

    • Decoralin (Insects, animals)

    • Source

    • Oreumenes decoratus (Potter wasp)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • SLLSLIRKLIT

    • Sequence Length

    • 11

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • [Ref.17981364]Gram-positive bacteria: Staphylococcus aureus CCT 6538 (MIC=40 µM), S. saprophyticus (MIC=40 µM), Bacillus subtilis CCT 2471 (MIC=40 µM), B. thuringiensis (MIC=40 µM);
      • Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=80 µM), Escherichia coli CCT 1371 (MIC=160 µM), Klebsiella pneumoniae ATCC 13883 (MIC=80 µM), A. faecalis ATCC 8750 (MIC=40 µM);
      • Fungi: Candida albicans (MIC=40 µM), L. major promastigotes (IC50=72 µM).

    • Hemolytic Activity

      • [Ref.17981364]EC50=1 mM against mouse erythrocytes

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Cell membrane

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03056 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03056.

Physicochemical Information

    • Formula

    • C58H109N15O15

    • Absent Amino Acids

    • ACDEFGHMNPQVWY

    • Common Amino Acids

    • L

    • Mass

    • 1256.59

    • PI

    • 11

    • Basic Residues

    • 2

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +2

    • Boman Index

    • -0.32

    • Hydrophobicity

    • 1.227

    • Aliphatic Index

    • 212.73

    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 3

DRAMP03056

Comments Information

    • Function

    • Linear cationic alpha-helical peptide that acts as antimicrobial peptide. At high concentrations exhibits activity in stimulating degranulation from rat peritoneal mast cells. Inhibits the growth of L.major promastigotes in vitro with an IC50 of 72 µM. Has hemolytic activity towards human and mouse erythrocytes.

    • Tissue specificity

    • Expressed by the venom gland.

Literature Information

  • ·Literature 1

    • Title

    • Decoralin, a novel linear cationic alpha-helical peptide from the venom of the solitary eumenine wasp Oreumenes decoratus.

    • Reference

    • Peptides. 2007 Dec;28(12):2320-2327.

    • Author

    • Konno K, Rangel M, Oliveira JS, Dos Santos Cabrera MP, Fontana R, Hirata IY, Hide I, Nakata Y, Mori K, Kawano M, Fuchino H, Sekita S, Neto JR.