General Information

    • DRAMP ID

    • DRAMP03058

    • Peptide Name

    • Phormia defensin A (insect defensin A, Ptdefensin A; Insects, animals)

    • Source

    • Phormia terranovae (Black blowfly)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • ATCDLLSGTGINHSACAAHCLLRGNRGGYCNGKGVCVCRN

    • Sequence Length

    • 40

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Combine helix and strand structure

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03058 helical wheel diagram

    • PDB ID

    • 1ICA resolved by NMR.

    • Predicted Structure

    • There is no predicted structure for DRAMP03058.

Physicochemical Information

    • Formula

    • C163H270N58O52S6

    • Absent Amino Acids

    • EFMPQW

    • Common Amino Acids

    • G

    • Mass

    • 4066.65

    • PI

    • 8.69

    • Basic Residues

    • 6

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +5

    • Boman Index

    • -52.81

    • Hydrophobicity

    • 0.048

    • Aliphatic Index

    • 73.25

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1865

    • Absorbance 280nm

    • 47.82

    • Polar Residues

    • 22

DRAMP03058

DRAMP03058 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Insect immunity: isolation from immune blood of the dipteran Phormia terranovae of two insect antibacterial peptides with sequence homology to Rabbit lung macrophage bactericidal peptides.

    • Reference

    • Proc Natl Acad Sci U S A. 1989 Jan;86(1):262-266.

    • Author

    • Lambert J, Keppi E, Dimarcq JL, Wicker C, Reichhart JM, Dunbar B, Lepage P, Van Dorsselaer A, Hoffmann J, Fothergill J, et al.