General Information

    • DRAMP ID

    • DRAMP03059

    • Peptide Name

    • Phormia defensin B (insect defensin B; Insects, animals)

    • Source

    • Phormia terranovae (Black blowfly)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • ATCDLLSGTGINHSACAAHCLLRGNRGGYCNRKGVCVCRN

    • Sequence Length

    • 40

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03059 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03059.

Physicochemical Information

    • Formula

    • C167H279N61O52S6

    • Absent Amino Acids

    • EFMPQW

    • Common Amino Acids

    • CG

    • Mass

    • 4165.79

    • PI

    • 8.96

    • Basic Residues

    • 7

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +6

    • Boman Index

    • -68.67

    • Hydrophobicity

    • -0.055

    • Aliphatic Index

    • 73.25

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1865

    • Absorbance 280nm

    • 47.82

    • Polar Residues

    • 21

DRAMP03059

DRAMP03059 chydropathy plot

Comments Information

    • It contains three intramolecular disulfide bridges and differ from one another by only a single amino acid. This peptide is neither functionally nor structurally related to any known insect immune response peptides but show significant homology to microbicidal cationic peptides from mammalian granulocytes (defensins).

Literature Information

  • ·Literature 1

    • Title

    • Insect immunity: isolation from immune blood of the dipteran Phormia terranovae of two insect antibacterial peptides with sequence homology to rabbit lung macrophage bactericidal peptides.

    • Reference

    • Proc Natl Acad Sci U S A. 1989 Jan;86(1):262-266.

    • Author

    • Lambert J, Keppi E, Dimarcq JL, Wicker C, Reichhart JM, Dunbar B, Lepage P, Van Dorsselaer A, Hoffmann J, Fothergill J, et al.