General Information

    • DRAMP ID

    • DRAMP03060

    • Peptide Name

    • S.calcitrans defensin 2 (Smd2; defensins; Insects, animals)

    • Source

    • Stomoxys calcitrans (Stable fly)

    • Family

    • Belongs to the invertebrate defensin family (Type 1 subfamily)

    • Gene

    • SMD2

    • Sequence

    • ATCDLLSMWNVNHSACAAHCLLLGKSGGRCNDDAVCVCRK

    • Sequence Length

    • 40

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03060 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03060.

Physicochemical Information

    • Formula

    • C173H284N56O54S7

    • Absent Amino Acids

    • EFIPQY

    • Common Amino Acids

    • C

    • Mass

    • 4236.92

    • PI

    • 7.83

    • Basic Residues

    • 6

    • Acidic Residues

    • 3

    • Hydrophobic Residues

    • 14

    • Net Charge

    • +3

    • Boman Index

    • -48.16

    • Hydrophobicity

    • 0.203

    • Aliphatic Index

    • 83

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5875

    • Absorbance 280nm

    • 150.64

    • Polar Residues

    • 16

DRAMP03060

DRAMP03060 chydropathy plot

Comments Information

    • Function

    • Antibacterial peptide active mostly against Gram-negative bacteria. Its activity is enhanced by lipopolysaccharide.

    • Tissue specificity

    • Constitutively expressed in the anterior midgut and is up-regulated by blood feeding. Not expressed in the fat body or hemocytes.

    • PTM

    • Contains three disulfide bonds (By similarity).

Literature Information

  • ·Literature 1

    • Title

    • Midgut-specific immune molecules are produced by the blood-sucking insect Stomoxys calcitrans.

    • Reference

    • Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11502-11507.

    • Author

    • Lehane MJ, Wu D, Lehane SM.