General Information

    • DRAMP ID

    • DRAMP03064

    • Peptide Name

    • Alloferon-1 (Insects, animals)

    • Source

    • Calliphora vicina (Blue blowfly) (Calliphora erythrocephala)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • HGVSGHGQHGVHG

    • Sequence Length

    • 13

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antiparasitic, Antiviral, Antitumor

    • Target Organism

    • Human influenza viruses A and B.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03064 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03064.

Physicochemical Information

    • Formula

    • C52H76N22O16

    • Absent Amino Acids

    • ACDEFIKLMNPRTWY

    • Common Amino Acids

    • G

    • Mass

    • 1265.31

    • PI

    • 7.1

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 2

    • Net Charge

    • +4

    • Boman Index

    • -14.8

    • Hydrophobicity

    • -0.823

    • Aliphatic Index

    • 44.62

    • Half Life

      • Mammalian:3.5 hour
      • Yeast:10 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 6

DRAMP03064

Comments Information

    • Function

    • Antimicrobial peptide presumably with antiparasitic, antiviral and/or Antitumoral activities.

    • Tissue specificity

    • Hemolymph.

    • Induction

    • By bacterial infection.

    • Miscellaneous

    • Stimulates antiviral and antitumoral resistance when injected in mice. Enhances natural cytotoxicity of blood and spleen lymphocytes. Induces interferon production in mouse and human.

Literature Information

  • ·Literature 1

    • Title

    • Antiviral and antitumor peptides from insects.

    • Reference

    • Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12628-32.

    • Author

    • Chernysh S, Kim SI, Bekker G, Pleskach VA, Filatova NA, Anikin VB, Platonov VG, Bulet P.