General Information
-
DRAMP ID
- DRAMP03065
-
Peptide Name
- Alloferon-2 (Insects, animals)
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Source
- Calliphora vicina (Blue blowfly) (Calliphora erythrocephala)
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- GVSGHGQHGVHG
-
Sequence Length
- 12
-
UniProt Entry
- No entry found
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Antifungal, Antiviral
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP03065.
Physicochemical Information
-
Formula
- C46H69N19O15
Absent Amino Acids
- ACDEFIKLMNPRTWY
Common Amino Acids
- G
Mass
- 1128.17
PI
- 7.02
Basic Residues
- 3
Acidic Residues
- 0
Hydrophobic Residues
- 2
Net Charge
- +3
-
Boman Index
- -10.14
Hydrophobicity
- -0.625
Aliphatic Index
- 48.33
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 6
DRAMP03065
Comments Information
Function
- Alloferon can (i) stimulate natural cytotoxicity of human peripheral blood lymphocytes, (ii) induces IFN synthesis in mouse and human models, and (iii) enhances antiviral and antitumor resistance in mice.
Literature Information
- ·Literature 1
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Title
- Antiviral and antitumor peptides from insects.
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Pubmed ID
- 12235362
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Reference
- Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12628-32.
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Author
- Chernysh S, Kim SI, Bekker G, Pleskach VA, Filatova NA, Anikin VB, Platonov VG, Bulet P.