General Information
-
DRAMP ID
- DRAMP03066
-
Peptide Name
- Lucifensin (Lucifensin II; Insects, animals)
-
Source
- Lucilia cuprina (Green bottle fly) (Australian sheep blowfly)
-
Family
- Belongs to the invertebrate defensin family (Type 1 subfamil
-
Gene
- Not found
-
Sequence
- ATCDLLSGTGIKHSACAAHCLLRGNRGGYCNGRAICVCRN
-
Sequence Length
- 40
-
UniProt Entry
- B3EWY5
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+
-
Target Organism
-
- Gram-positive bacterium: Micrococcus luteus.
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP03066.
Physicochemical Information
-
Formula
- C167H280N60O51S6
Absent Amino Acids
- EFMPQW
Common Amino Acids
- CG
Mass
- 4136.79
PI
- 8.96
Basic Residues
- 7
Acidic Residues
- 1
Hydrophobic Residues
- 12
Net Charge
- +6
-
Boman Index
- -59.34
Hydrophobicity
- 0.085
Aliphatic Index
- 78.25
Half Life
-
- Mammalian:4.4 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 1865
Absorbance 280nm
- 47.82
Polar Residues
- 20
DRAMP03066
Comments Information
Function
- May have antibacterial activity.
Tissue specificity
- Larval fat body, hemolymph and salivary glands (at protein level).
PTM
- Contains three disulfide bonds 3-30; 16-36; 20-38.
Literature Information
- ·Literature 1
-
Title
- Lucifensin II, the defensin of medicinal maggots of the blowfly Lucilia cuprina.
-
Pubmed ID
- PubMed ID is not available
-
Reference
- Submitted (DEC-2012) to UniProtKB
-
Author
- El Shazely B, Veverka V, Fucik V, Voburka Z, Zdarek J, Cerovsky V.