General Information

    • DRAMP ID

    • DRAMP03067

    • Peptide Name

    • Lucifensin (Lucilia defensin; Insects, animals)

    • Source

    • Lucilia sericata (Green bottle fly) (Phaenicia sericata)

    • Family

    • Belongs to the invertebrate defensin family (Type 1 subfamil

    • Gene

    • Not found

    • Sequence

    • ATCDLLSGTGVKHSACAAHCLLRGNRGGYCNGRAICVCRN

    • Sequence Length

    • 40

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacterium: Micrococcus luteus.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Combine helix and strand structure

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03067 helical wheel diagram

    • PDB ID

    • 2LLD resolved by NMR.

    • Predicted Structure

    • There is no predicted structure for DRAMP03067.

Physicochemical Information

    • Formula

    • C166H278N60O51S6

    • Absent Amino Acids

    • EFMPQW

    • Common Amino Acids

    • CG

    • Mass

    • 4122.76

    • PI

    • 8.96

    • Basic Residues

    • 7

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 12

    • Net Charge

    • +6

    • Boman Index

    • -60.22

    • Hydrophobicity

    • 0.078

    • Aliphatic Index

    • 75.75

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1865

    • Absorbance 280nm

    • 47.82

    • Polar Residues

    • 20

DRAMP03067

DRAMP03067 chydropathy plot

Comments Information

    • Function

    • May have antibacterial activity.

    • Tissue specificity

    • Larval fat body, hemolymph and salivary glands (at protein level).

    • PTM

    • Contains three disulfide bonds 3-30; 16-36; 20-38 (By similarity).

Literature Information

  • ·Literature 1

    • Title

    • Lucifensin, the long-sought antimicrobial factor of medicinal maggots of the blowfly Lucilia sericata.

    • Reference

    • Cell Mol Life Sci. 2010 Feb;67(3):455-466.

    • Author

    • Cerovský V, Zdárek J, Fucík V, Monincová L, Voburka Z, Bém R.
  • ·Literature 2

    • Title

    • The insect defensin lucifensin from Lucilia sericata.

    • Reference

    • J Biomol NMR. 2012 Mar;52(3):277-282.

    • Author

    • Nygaard MK, Andersen AS, Kristensen HH, Krogfelt KA, Fojan P, Wimmer R.