General Information
-
DRAMP ID
- DRAMP03069
-
Peptide Name
- Diptericin (Insects, animals)
-
Source
- Sarcophaga peregrina (Flesh fly)
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Family
- Belongs to the attacin/sarcotoxin-2 family
-
Gene
- Not found
-
Sequence
- DLHIPPPDNKINWPQLSGGGGGSPKTGYDININAQQK
-
Sequence Length
- 37
-
UniProt Entry
- Q9TWW2
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial
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Target Organism
- Escherichia coli (MIC=6.25 µg/ml), Shigella sonnei (MIC=12.5 µg/ml).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Free
-
Nonterminal Modifications and Unusual Amino Acids
- Free
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- Please click DRAMP03069_predicted_structure.pdb to download.
Physicochemical Information
-
Formula
- C173H268N50O55
Absent Amino Acids
- CEFMRV
Common Amino Acids
- G
Mass
- 3928.33
PI
- 6.75
Basic Residues
- 4
Acidic Residues
- 3
Hydrophobic Residues
- 8
Net Charge
- +1
-
Boman Index
- -60.86
Hydrophobicity
- -1.011
Aliphatic Index
- 65.95
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:>10 hour
Extinction Coefficient Cystines
- 6990
Absorbance 280nm
- 194.17
Polar Residues
- 14
DRAMP03069
Comments Information
By injury to the body wall of the larva. Expression peaks at 10 hours post-injury and is maintained at this level for at least 3 days.
Literature Information
- ·Literature 1
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Title
- Purification and characterization of a diptericin homologue from Sarcophaga peregrina (flesh fly).
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Pubmed ID
- 1445217
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Reference
- Biochem J. 1992 Oct 15;287 (Pt 2):573-578.
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Author
- Ishikawa M, Kubo T, Natori S.