General Information
-
DRAMP ID
- DRAMP03076
-
Peptide Name
- Cecropin-1 (Cecropin 1; Insects, animals)
-
Source
- Ceratitis capitata (Mediterranean Fruit fly)
-
Family
- Belongs to the cecropin family
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Gene
- CEC1
-
Sequence
- GWLKKIGKKIERVGQHTRDATIQTIAVAQQAANVAATAR
-
Sequence Length
- 39
-
UniProt Entry
- Q06589
-
Protein Existence
- Homology
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP03076.
Physicochemical Information
-
Formula
- C183H312N60O53
Absent Amino Acids
- CFMPSY
Common Amino Acids
- A
Mass
- 4200.86
PI
- 11.07
Basic Residues
- 8
Acidic Residues
- 2
Hydrophobic Residues
- 17
Net Charge
- +6
-
Boman Index
- -69.88
Hydrophobicity
- -0.331
Aliphatic Index
- 92.82
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 5500
Absorbance 280nm
- 144.74
Polar Residues
- 8
DRAMP03076
Comments Information
Function
- Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria.
PTM
- C-terminal amidation (By similarity).
Literature Information
- ·Literature 1
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Title
- Sequences of two cDNA clones from the medfly Ceratitis capitata encoding antibacterial peptides of the cecropin family.
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Pubmed ID
- 7916722
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Reference
- Gene. 1993 Dec 8;134(2):241-243.
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Author
- Rosetto M, Manetti AG, Marchini D, Dallai R, Telford JL, Baldari CT.