General Information

    • DRAMP ID

    • DRAMP03079

    • Peptide Name

    • Cecropin-A1 (Insects, animals)

    • Source

    • Drosophila mauritiana (Fruit fly)

    • Family

    • Belongs to the cecropin family

    • Gene

    • CecA1

    • Sequence

    • GWLKKIGKKIERVGQHTRDATIQGLGVAQQAANVAATAR

    • Sequence Length

    • 39

    • Protein Existence

    • Homology

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03079 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03079.

Physicochemical Information

    • Formula

    • C180H306N60O52

    • Absent Amino Acids

    • CFMPSY

    • Common Amino Acids

    • A

    • Mass

    • 4142.78

    • PI

    • 11.07

    • Basic Residues

    • 8

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 16

    • Net Charge

    • +6

    • Boman Index

    • -67.24

    • Hydrophobicity

    • -0.397

    • Aliphatic Index

    • 90.26

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 144.74

    • Polar Residues

    • 9

DRAMP03079

DRAMP03079 chydropathy plot

Comments Information

    • Function

    • Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria (By similarity).

    • PTM

    • C-terminal amidation (By similarity).

Literature Information

  • ·Literature 1

    • Title

    • Molecular population genetics of Drosophila immune system genes.

    • Reference

    • Genetics. 1997 Oct;147(2):713-724.

    • Author

    • Clark AG, Wang L.
  • ·Literature 2

    • Title

    • Molecular evolution of the Cecropin multigene family in Drosophila. functional genes vs. pseudogenes.

    • Reference

    • Genetics. 1998 Sep;150(1):157-171.

    • Author

    • Ramos-Onsins S, Aguadé M.