General Information

    • DRAMP ID

    • DRAMP03085

    • Peptide Name

    • Ceratotoxin-A (Insects, animals)

    • Source

    • Ceratitis capitata (Mediterranean Fruit fly)

    • Family

    • Not found

    • Gene

    • CTXA1

    • Sequence

    • SIGSALKKALPVAKKIGKIALPIAKAALP

    • Sequence Length

    • 29

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

    • [Swiss_Prot Entry P36190]Female-specific peptides with potent activity against Gram-positive and Gram-negative bacteria

    • Hemolytic Activity

      • [Swiss_Prot Entry P36190]has hemolytic activity

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Alpha helix

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03085 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03085.

Physicochemical Information

    • Formula

    • C135H243N35O32

    • Absent Amino Acids

    • CDEFHMNQRTWY

    • Common Amino Acids

    • A

    • Mass

    • 2868.63

    • PI

    • 10.7

    • Basic Residues

    • 6

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 16

    • Net Charge

    • +6

    • Boman Index

    • 17.85

    • Hydrophobicity

    • 0.669

    • Aliphatic Index

    • 141.72

    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 4

DRAMP03085

DRAMP03085 chydropathy plot

Comments Information

    • Function

    • Female-specific peptides with potent activity against Gram-positive and Gram-negative bacteria. Has hemolytic activity.

    • Temperature dependence

    • Thermostable. Still active at 100 degrees Celsius.

Literature Information

  • ·Literature 1

    • Title

    • Purification and primary structure of ceratotoxin A and B, two antibacterial peptides from the female reproductive accessory glands of the medfly Ceratitis capitata (Insecta:Diptera).

    • Reference

    • Insect Biochem Mol Biol. 1993 Jul;23(5):591-598.

    • Author

    • Marchini D, Giordano PC, Amons R, Bernini LF, Dallai R.
  • ·Literature 2

    • Title

    • cDNA sequence and expression of the ceratotoxin gene encoding an antibacterial sex-specific peptide from the medfly Ceratitis capitata (diptera).

    • Reference

    • J Biol Chem. 1995 Mar 17;270(11):6199-6204.

    • Author

    • Marchini D, Manetti AG, Rosetto M, Bernini LF, Telford JL, Baldari CT, Dallai R.