General Information

    • DRAMP ID

    • DRAMP03086

    • Peptide Name

    • Ceratotoxin-D (Insects, animals)

    • Source

    • Ceratitis capitata (Mediterranean Fruit fly) (Tephritis capitata)

    • Family

    • Not found

    • Gene

    • CTXD

    • Sequence

    • SIGTAVKKAVPIAKKVGKVAIPIAKAVLSVVGQLVG

    • Sequence Length

    • 36

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

    • [Swiss_Prot Entry O17513]Female-specific peptides with potent activity against Gram-positive and Gram-negative bacteria

    • Hemolytic Activity

      • [Swiss_Prot Entry O17513]has hemolytic activity

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03086 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03086.

Physicochemical Information

    • Formula

    • C163H293N43O41

    • Absent Amino Acids

    • CDEFHMNRWY

    • Common Amino Acids

    • V

    • Mass

    • 3511.38

    • PI

    • 10.7

    • Basic Residues

    • 6

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 20

    • Net Charge

    • +6

    • Boman Index

    • 28.25

    • Hydrophobicity

    • 1

    • Aliphatic Index

    • 146.11

    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 7

DRAMP03086

DRAMP03086 chydropathy plot

Comments Information

    • Function

    • Female-specific peptides with potent activity against Gram-positive and Gram-negative bacteria. Has hemolytic activity.

    • Biophysicochemical properties

    • Temperature dependence (Thermostable. Still active at 100 degrees Celsius).

Literature Information

  • ·Literature 1

    • Title

    • The genes encoding the antibacterial sex-specific peptides ceratotoxins are clustered in the genome of the medfly Ceratitis capitata.

    • Reference

    • Insect Biochem Mol Biol. 1997 Dec;27(12):1039-1046.

    • Author

    • Rosetto M, De Filippis T, Manetti AG, Marchini D, Baldari CT, Dallai R.