General Information

    • DRAMP ID

    • DRAMP03096

    • Peptide Name

    • Metchnikowin-2 (Insects, animals)

    • Source

    • Drosophila melanogaster (Fruit fly)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • RRQGPIFDTRPSPFNPNQPRPGPIY

    • Sequence Length

    • 25

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Antifungal

    • Target Organism

      • Gram-positive bacterium: Micrococcus luteus (MIC=0.5-1.0 µM).
      • Fungi: Neurospora crassa (MIC=0.5-1.0 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03096 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03096.

Physicochemical Information

    • Formula

    • C131H199N41O35

    • Absent Amino Acids

    • ACEHKLMVW

    • Common Amino Acids

    • P

    • Mass

    • 2908.27

    • PI

    • 11.54

    • Basic Residues

    • 4

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 4

    • Net Charge

    • +3

    • Boman Index

    • -81.19

    • Hydrophobicity

    • -1.428

    • Aliphatic Index

    • 31.2

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 62.08

    • Polar Residues

    • 7

DRAMP03096

DRAMP03096 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Metchnikowin, a novel immune-inducible proline-rich peptide from Drosophila with antibacterial and antifungal properties.

    • Reference

    • Eur J Biochem. 1995 Oct 15;233(2):694-700.

    • Author

    • Levashina EA, Ohresser S, Bulet P, Reichhart JM, Hetru C, Hoffmann JA.