General Information

    • DRAMP ID

    • DRAMP03098

    • Peptide Name

    • Metchnikowin (Pro-rich; Insects, animals)

    • Source

    • Drosophila melanogaster (Common fruit fly)

    • Family

    • Not found

    • Gene

    • Mtk

    • Sequence

    • HRHQGPIFDTRPSPFNPNQPRPGPIY

    • Sequence Length

    • 26

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal

    • Target Organism

    • Micrococcus luteus (MIC=0.5-1.0 µg/ml), Neurospora crassa (MIC=0.5-1.0 µg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Rich in Proline

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03098 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03098.

Physicochemical Information

    • Formula

    • C137H201N43O36

    • Absent Amino Acids

    • ACEKLMVW

    • Common Amino Acids

    • P

    • Mass

    • 3026.37

    • PI

    • 10.74

    • Basic Residues

    • 5

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 4

    • Net Charge

    • +4

    • Boman Index

    • -75.59

    • Hydrophobicity

    • -1.446

    • Aliphatic Index

    • 30

    • Half Life

      • Mammalian:3.5 hour
      • Yeast:10 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 59.6

    • Polar Residues

    • 7

DRAMP03098

DRAMP03098 chydropathy plot

Comments Information

    • Transgenic plants

    • Insect peptide metchnikowin confers on barley a selective capacity for resistance to fungal ascomycetes pathogens (J Exp Bot. 2009;60(14)

Literature Information

  • ·Literature 1

    • Title

    • Metchnikowin, a novel immune-inducible proline-rich peptide from Drosophila with antibacterial and antifungal properties.

    • Reference

    • Eur J Biochem. 1995 Oct 15;233(2):694-700.

    • Author

    • Levashina E.A, Ohresser S, Bulet P, Reichhart JM, Hetru C, Hoffmann J.A.