General Information

    • DRAMP ID

    • DRAMP03102

    • Peptide Name

    • Sarcotoxin-1B (Sarcotoxin IB; Insects, animals)

    • Source

    • Sarcophaga peregrina (Flesh fly) (Boettcherisca peregrina)

    • Family

    • Belongs to the cecropin family

    • Gene

    • Not found

    • Sequence

    • GWLKKIGKKIERVGQHTRDATIQVIGVAQQAANVAATAR

    • Sequence Length

    • 39

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-

    • Target Organism

      • Gram-negative bacterium: Escherichia coli.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03102 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03102.

Physicochemical Information

    • Formula

    • C183H312N60O52

    • Absent Amino Acids

    • CFMPSY

    • Common Amino Acids

    • A

    • Mass

    • 4184.86

    • PI

    • 11.07

    • Basic Residues

    • 8

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 17

    • Net Charge

    • +6

    • Boman Index

    • -64.14

    • Hydrophobicity

    • -0.262

    • Aliphatic Index

    • 97.69

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 144.74

    • Polar Residues

    • 8

DRAMP03102

DRAMP03102 chydropathy plot

Comments Information

    • Function

    • Sarcotoxins, which are potent bactericidal proteins, are produced in response to injury. They are cytotoxic to both Gram-positive and Gram-negative bacteria.

    • PTM

    • Problely Arginine amide at R39.

Literature Information

  • ·Literature 1

    • Title

    • Primary structure of sarcotoxin I, an antibacterial protein induced in the hemolymph of Sarcophaga peregrina (flesh fly) larvae.

    • Reference

    • J Biol Chem. 1985 Jun 25;260(12):7174-7177.

    • Author

    • Okada M, Natori S.
  • ·Literature 2

    • Title

    • Cloning of gene cluster for sarcotoxin I, antibacterial proteins of Sarcophaga peregrina.

    • Reference

    • FEBS Lett. 1989 Dec 4;258(2):199-202.

    • Author

    • Kanai A, Natori S.