• DRAMP ID

    • DRAMP03113
    • Peptide Name

    • SK84 (Gly-rich; Insects, animals)
    • Source

    • Drosophila virilis (Fruit fly)
    • Family

    • Unknow
    • Gene

    • Unknow
    • Sequence

    • SQLGDLGSGAGQGGGGGGSIRAAGGAFGKLEAAREEEFFYKKQKEQLERLKNDQIHQAEFHHQQIKEHEEAIQRHKDFLNNLHK
    • Sequence Length

    • 84
    • Swiss_Prot Entry

    • No entry found
    • Evidence code

    • Unknow
    • Biological Activity

    • Antibacterial, Antifungal, Antiviral, In
    • Target Organism

      • Gram-positive bacteria: Bacillus thuringiensis ATCC 1041 (MIC=4 µM), B. subtilis ATCC 9372 (MIC=8 µM), Staphylococcus aureus ATCC 6538 (MIC=8 µM).
    • Hemolytic activity

    • Unknown
    • Binding Traget

    • Unknow
    • Structure

    • Unknow
    • Structure Description

    • Unknow
    • PDB ID

    • Unknow
    • DRAMP03113 helical wheel diagram
    • Formula

    • C406H632N128O127
    • Absent Amino Acids

    • CMPTVW
    • Common Amino Acids

    • G
    • Mass

    • 10000
    • PI

    • 7.18
    • Basic Residues

    • 18
    • Acidic Residues

    • 13
    • Hydrophobic Residues

    • 24
    • Boman Index

    • -210.7
    • Hydrophobicity

    • -109.29
    • Aliphatic Index

    • 60.6
    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 1490
    • Absorbance 280nm

    • 17.95
    • Polar Residues

    • 20

DRAMP03113

DRAMP03113 chydropathy plot
    • Function

    • SK84 displays antibacterial activity against the tested Gram-positive bacteria (B. subtilis, Bacillus thuringiensis and Staphylococcus aureus), but had no effect on Gram-negative bacteria (Pseudomonas aeruginosa, Escherichia coli) and fungi (Saccharomyces cerevisiae, Candida albicans). Has no hemolytic activity.
  • Literature 1
    • Reference

    • Peptides. 2010 Jan;31(1):44-50.
    • Author

    • Lu J, Chen ZW.
    • Title

    • Isolation, characterization and anti-cancer activity of SK84, a novel glycine-rich antimicrobial peptide from Drosophila virilis.