General Information

    • DRAMP ID

    • DRAMP03113

    • Peptide Name

    • SK84 (Gly-rich; Insects, animals)

    • Source

    • Drosophila virilis (Fruit fly)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • SQLGDLGSGAGQGGGGGGSIRAAGGAFGKLEAAREEEFFYKKQKEQLERLKNDQIHQAEFHHQQIKEHEEAIQRHKDFLNNLHK

    • Sequence Length

    • 84

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Antifungal, Antiviral

    • Target Organism

      • [Ref.19799950]Gram-positive bacteria: Bacillus thuringiensis ATCC 1041 (MIC=4 µM), B. subtilis ATCC 9372 (MIC=8 µM), Staphylococcus aureus ATCC 6538 (MIC=8 µM).

    • Hemolytic Activity

      • [Ref.19799950]0.01% hemolytic activity at 100 μM against human red blood cells

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03113 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C406H632N128O127

    • Absent Amino Acids

    • CMPTVW

    • Common Amino Acids

    • G

    • Mass

    • 9338.27

    • PI

    • 6.57

    • Basic Residues

    • 18

    • Acidic Residues

    • 13

    • Hydrophobic Residues

    • 24

    • Net Charge

    • +5

    • Boman Index

    • -210.7

    • Hydrophobicity

    • -1.093

    • Aliphatic Index

    • 60.6

    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 17.95

    • Polar Residues

    • 20

DRAMP03113

DRAMP03113 chydropathy plot

Comments Information

    • Function

    • SK84 displays antibacterial activity against the tested Gram-positive bacteria (B. subtilis, Bacillus thuringiensis and Staphylococcus aureus), but had no effect on Gram-negative bacteria (Pseudomonas aeruginosa, Escherichia coli) and fungi (Saccharomyces cerevisiae, Candida albicans). Has weak hemolytic activity.

Literature Information

  • ·Literature 1

    • Title

    • Isolation, characterization and anti-cancer activity of SK84, a novel glycine-rich antimicrobial peptide from Drosophila virilis.

    • Reference

    • Peptides. 2010 Jan;31(1):44-50.

    • Author

    • Lu J, Chen ZW.