• • DRAMP ID

  • DRAMP03117

• • Peptide Name

  • Drosophila cecropin-A1 (Insects, animals)

• • Source

  • Drosophila simulans (Fruit fly)

• • Family

  • Belongs to the cecropin family

• • Gene

  • CecA1

• • Sequence

  • QSEAGWLKKIGKKIERVGQHTRDATIQGLGVAQQAPNVAATAR

• • Sequence Length

  • 43

• • UniProt Entry

  • O61272

• • Protein Existence

  • Homology

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

• • Target Organism

  • • Gram-negative bacteria: Alcaligenes faecalis (MIC=10-25 µM), Escherichia coli 1106 (MIC=0.25-0.5 µM), Escherichia coli D22 (MIC=0.1-0.25 µM), Escherichia coli D31 (MIC=0.1-0.25 µM), Escherichia coli SBS363 (MIC=0.1-0.25 µM), Enterobacter cloacae β12 (MIC=0.5-1 µM), Erwinia carotovora (MIC=0.5-1 µM), Klebsiella pneumoniae (MIC=1-2.5 µM), Pseudomonas aeruginosa (MIC=1-2.5 µM), Salmonella typhimurium (MIC=0.5-1 µM), Xanthomonas campestris (MIC=0.5-1 µM);
    • Gram-positive bacteria: Aerococcus viridans (MIC=5-10 µM), Bacillus megaterium (MIC=1-2.5 µM), Micrococcus luteus (MIC=5-10 µM).
    • Fungi: Botrytis cinerea (MIC=5-10 µM), Fusarium culmorum (MIC=1-2.5 µM), Fusarium oxysporum (MIC=1-2.5 µM), Neurospora crassa (MIC=2.5-10 µM).

• • Hemolytic Activity

  • • No hemolysis information or data found in the reference(s) presented in this entry

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Not included yet

• • N-terminal Modification

  • Not included yet

• • C-terminal Modification

  • Not included yet

• • Nonterminal Modifications and Unusual Amino Acids

  • Not included yet

• • Stereochemistry

  • Not included yet

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• Please click DRAMP03117_predicted_structure.pdb to download.

DRAMP03117

• • Function

  • Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria.

• • PTM

  • C-terminal amidation (By similarity).

• ·Literature 1

• • Title

  • Evolutionary history and mechanism of the Drosophila cecropin gene family.

• • Pubmed ID

  • 9553148

• • Reference

  • Immunogenetics. 1998 May;47(6):417-429.

• • Author

  • Date A, Satta Y, Takahata N, Chigusa S.I.

• ·Literature 2

• • Title

  • Molecular evolution of the Cecropin multigene family in Drosophila: functional genes vs pseudogenes.

• • Pubmed ID

  • 9725836

• • Reference

  • Genetics. 1998 Sep;150(1):157-171.

• • Author

  • Ramos-Onsins S, Aguade M.