General Information
-
DRAMP ID
- DRAMP03119
-
Peptide Name
- Def-BAT (hybrid defensins; Insects, animals)
-
Source
- Anopheles gambiae (African malaria mosquito)
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- ATCDLASFSSQWVTPNDSLCAAHCIARRYRGGYCNGKRVCVCR
-
Sequence Length
- 43
-
UniProt Entry
- Q17027
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+
-
Target Organism
-
- Gram-positive bacteria: Staphylococcus aureus strain 21 (IC90=6.25 µg/mL), Staphylococcus aureus strain 4 (IC90=6.25 µg/mL).
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Alpha helix (1 helices; 7 residues)
-
Structure Description
- For Def-BAT, the two extended strands do not form an anti-parallel β-sheet. The helix is separated from the β-sheet by a turn (T1) and the two strands of the b-sheet by turn T2.
-
Helical Wheel Diagram
-
PDB ID
- 2E3F resolved by NMR.
-
Predicted Structure
- There is no predicted structure for DRAMP03119.
Physicochemical Information
-
Formula
- C198H313N65O59S6
Absent Amino Acids
- EM
Common Amino Acids
- C
Mass
- 4740.42
PI
- 8.94
Basic Residues
- 7
Acidic Residues
- 2
Hydrophobic Residues
- 13
Net Charge
- +5
-
Boman Index
- -88.35
Hydrophobicity
- -0.151
Aliphatic Index
- 59.07
Half Life
-
- Mammalian:4.4 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 8855
Absorbance 280nm
- 210.83
Polar Residues
- 19
DRAMP03119
Comments Information
Function
- Responsible for the anti Gram-positive activity of immune hemolymph and proves to be efficient against sensitive
strains as against resistant and multi-resistant strains.
Literature Information
- ·Literature 1
-
Title
- Rational design of peptides active against the gram positive bacteria Staphylococcus aureus.
-
Pubmed ID
- 18214975
-
Reference
- Proteins. 2008 Jul;72(1):229-239.
-
Author
- Landon C, Barbault F, Legrain M, Guenneugues M, Vovelle F.