General Information

    • DRAMP ID

    • DRAMP03127

    • Peptide Name

    • Cecropin-A (Insects, animals)

    • Source

    • Culex pipiens pipiens (Northern house mosquito)

    • Family

    • Not found

    • Gene

    • CECA

    • Sequence

    • GGLKKFGKKLEGVGKRVFKASEKALPVVTGFKAL

    • Sequence Length

    • 34

    • Protein Existence

    • Homology

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03127 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03127.

Physicochemical Information

    • Formula

    • C168H283N45O41

    • Absent Amino Acids

    • CDHIMNQWY

    • Common Amino Acids

    • K

    • Mass

    • 3589.37

    • PI

    • 10.47

    • Basic Residues

    • 9

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 14

    • Net Charge

    • +7

    • Boman Index

    • -23.06

    • Hydrophobicity

    • -0.071

    • Aliphatic Index

    • 88.82

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 8

DRAMP03127

DRAMP03127 chydropathy plot

Comments Information

    • Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria

Literature Information

  • ·Literature 1

    • Title

    • Innate immunity in the Culex pipiens-Wuchereria bancrofti host-parasite relationship.

    • Reference

    • Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.

    • Author

    • Bartholomay L.C, Farid H.A, Ramzy R.M, Christensen B.M.