General Information

    • DRAMP ID

    • DRAMP03138

    • Peptide Name

    • Cecropin-A (Insects, animals)

    • Source

    • Aedes aegypti (Yellowfever mosquito)

    • Family

    • Belongs to the cecropin family

    • Gene

    • CECA

    • Sequence

    • GGLKKLGKKLEGAGKRVFNAAEKALPVVAGAKAL

    • Sequence Length

    • 34

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-negative bacteria: Escherichia coli D22 (MIC=0.25-0.5 µg/ml), E. coli D31 (MIC=0.25-0.5 µg/ml), E. coli SBS363 (MIC=0.1-0.25 µg/ml), E. coli 1106 (MIC=0.25-0.5 µg/ml), Enterobacter cloacae b12 (MIC=50-100 µg/ml), E. carotovora (MIC=0.25-0.5 µg/ml), Klebsiella pneumoniae (MIC=1-2.5 µg/ml), Pseudomonas aeruginosa (MIC=10-25 µg/ml), Salmonella typhimurium (MIC=1-2.5 µg/ml), X. campestris (MIC=0.5-1 µg/ml);
      • Gram-positive bacteria: Aerococcus viridans (MIC=2.5-5 µg/ml), Bacillus megaterium (MIC=1-2.5 µg/ml), Micrococcus luteus (MIC=10-25 µg/ml), Streptococcus pyogenes (MIC=10-25 µg/ml).
      • Fungi: Fusarium culmorum (MIC=1-2.5 µg/ml), Fusarium oxysporum (MIC=2.5-5 µg/ml), Neurospora crassa (MIC=5-10 µg/ml), Candida albicans (MIC=25-50 µg/ml), Cryptococcus neoformans (MIC=25-50 µg/ml), Saccharomyces cerevisiae (MIC=50-100 µg/ml)

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Linear

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03138 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03138.

Physicochemical Information

    • Formula

    • C154H269N45O40

    • Absent Amino Acids

    • CDHIMQSTWY

    • Common Amino Acids

    • AK

    • Mass

    • 3391.11

    • PI

    • 10.39

    • Basic Residues

    • 8

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 16

    • Net Charge

    • +6

    • Boman Index

    • -16.02

    • Hydrophobicity

    • 0.021

    • Aliphatic Index

    • 103.53

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 7

DRAMP03138

DRAMP03138 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial activity spectrum, cDNA cloning, and mRNA expression of a newly isolated member of the cecropin family from the mosquito vector Aedes aegypti.

    • Reference

    • J Biol Chem. 1999 Jul 16;274(29):20092-20097.

    • Author

    • Lowenberger C, Charlet M, Vizioli J, Kamal S, Richman A, Christensen BM, Bulet P.