General Information
-
DRAMP ID
- DRAMP03152
-
Peptide Name
- Spodoptera cecropins B (insects, invertebrates, animals)
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Source
- Spodoptera litura larvae (Common cutworm)
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Family
- Belongs to the cecropin family
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Gene
- CECB
-
Sequence
- RWKVFKKIEKMGRNIRDGIVKAGPAIEVLGSAKALGK
-
Sequence Length
- 37
-
UniProt Entry
- Q9XZH0
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP03152.
Physicochemical Information
-
Formula
- C184H315N55O46S
Absent Amino Acids
- CHQTY
Common Amino Acids
- K
Mass
- 4065.93
PI
- 10.71
Basic Residues
- 10
Acidic Residues
- 3
Hydrophobic Residues
- 15
Net Charge
- +7
-
Boman Index
- -54.75
Hydrophobicity
- -0.27
Aliphatic Index
- 97.57
Half Life
-
- Mammalian:1 hour
- Yeast:2 min
- E.coli:2 min
Extinction Coefficient Cystines
- 5500
Absorbance 280nm
- 152.78
Polar Residues
- 7
DRAMP03152
Comments Information
Function
- Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria.
Induction
- Induced as part of the humoral response to a bacterial invasion. Transcripts appear within the immunized fat body.
Tissue specificity
- Expressed in immunized fat body.
NOTE
- It retains antibacterial activities in all conditions tested (at pH 5.6-8.0 and in the presence of 50-150 mM NaCl) that was adapted to confirm the antibacterial properties of Spodoptera cecropins.
Literature Information
- ·Literature 1
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Title
- Antibacterial properties and partial cDNA sequences of cecropin-like antibacterial peptides from the common cutworm, Spodoptera litura.
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Pubmed ID
- 11790350
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Reference
- Comp Biochem Physiol C Toxicol Pharmacol. 2000 Mar;125(3):287-297.
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Author
- Choi CS, Lee IH, Kim E, Kim SI, Kim HR.