• • DRAMP ID

  • DRAMP03153

• • Peptide Name

  • 27 kDa antibacterial protein

• • Source

  • Cyprinus carpio (common carp)

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • GIGGKPVQTAFVDNDGIYD

• • Sequence Length

  • 19

• • UniProt Entry

  • P81925

• • Protein Existence

  • Protein level

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

• • Target Organism

  • • Gram-positive bacteria: Staphylococcus aureus (MIC=5 µg/ml), Micrococcus luteus (MIC=0. 5 µg/ml);
    • Gram-negative bacteria: Escherichia coli (MIC=5 µg/ml), Pseudomonas fluorescens (MIC=10 µg/ml), Aeromonas hydrophila (MIC=5 µg/ml).

• • Hemolytic Activity

  • • No hemolysis information or data found in the reference(s) presented in this entry

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • Cell membrane

• • Linear/Cyclic

  • Not included yet

• • N-terminal Modification

  • Not included yet

• • C-terminal Modification

  • Not included yet

• • Nonterminal Modifications and Unusual Amino Acids

  • Not included yet

• • Stereochemistry

  • Not included yet

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• Please click DRAMP03153_predicted_structure.pdb to download.

DRAMP03153

• • Function

  • Has antibacterial activity. Forms large ion channels responsible for disrupting the cellular envelope of bacteria leading to cell lysis.

• ·Literature 1

• • Title

  • Characterization and ion channel activities of novel antibacterial proteins from the skin mucosa of carp (Cyprinus carpio).

• • Pubmed ID

  • 8797847

• • Reference

  • Eur J Biochem. 1996 Aug 15;240(1):143-149.

• • Author

  • Lemaître C, Orange N, Saglio P, Saint N, Gagnon J, Molle G.