General Information
-
DRAMP ID
- DRAMP03154
-
Peptide Name
- Hadrurin (Non-disulfide-bridged peptide 3.1)
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Source
- Hadrurus aztecus
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Family
- Belongs to the antimicrobial peptide scorpion family
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Gene
- Not found
-
Sequence
- GILDTIKSIASKVWNSKTVQDLKRKGINWVANKLGVSPQAA
-
Sequence Length
- 41
-
UniProt Entry
- P82656
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Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram-
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Target Organism
-
- Gram-negative bacteria: Salmonella typhimurium, Klebsiella pneumoniae, Enterobacter cloacae, Pseudomonas aeruginosa, Escherichia coli, Serratia marcescens.
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP03154.
Physicochemical Information
-
Formula
- C199H333N57O57
Absent Amino Acids
- CEFHMY
Common Amino Acids
- K
Mass
- 4436.18
PI
- 10.3
Basic Residues
- 7
Acidic Residues
- 2
Hydrophobic Residues
- 17
Net Charge
- +5
-
Boman Index
- -50.08
Hydrophobicity
- -0.2
Aliphatic Index
- 104.63
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 11000
Absorbance 280nm
- 275
Polar Residues
- 12
DRAMP03154
Comments Information
Function
- Has antimicrobial activity. Also shows cytolytic activity when tested in human erythrocytes.
Literature Information
- ·Literature 1
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Title
- Hadrurin, a new antimicrobial peptide from the venom of the scorpion Hadrurus aztecus.
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Pubmed ID
- 10931184
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Reference
- Eur J Biochem. 2000 Aug;267(16):5023-5031.
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Author
- Torres-Larios A, Gurrola GB, Zamudio FZ, Possani LD.