General Information
-
DRAMP ID
- DRAMP03155
-
Peptide Name
- Sillucin
-
Source
- Rhizomucor pusillus
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- ACLPNSCVSKGCCCGBSGYWCRQCGIKYTC
-
Sequence Length
- 30
-
UniProt Entry
- P02885
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial
-
Target Organism
- No MICs found in DRAMP database
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Bridge
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP03155.
Physicochemical Information
-
Formula
- C126H195N37O37S8
Absent Amino Acids
- DEFHM
Common Amino Acids
- C
Mass
- 3209.31
PI
- 8.52
Basic Residues
- 3
Acidic Residues
- 0
Hydrophobic Residues
- 5
Net Charge
- +3
-
Boman Index
- -19.23
Hydrophobicity
- 0.173
Aliphatic Index
- 39
Half Life
-
- Mammalian:4.4 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 8980
Absorbance 280nm
- 309.66
Polar Residues
- 19
DRAMP03155
Comments Information
Function
- Sillucin is an antimicrobial agent produced by the thermophilic fungus Rhizomucor pusillus in liquid culture; it is effective against Gram-positive bacteria at the level of RNA metabolism.
PTM
- Contains four disulfide bonds 2-7; 12-24; 13-30; 14-21.
Literature Information
- ·Literature 1
-
Title
- The primary structure of sillucin and antimicrobial peptide from Mucor pusillus.
-
Pubmed ID
- 761621
-
Reference
- FEBS Lett. 1979 Jan 1;97(1):81-83.
-
Author
- Bradley WA, Somkuti GA.
- ·Literature 2
-
Title
- Determination of the disulfide structure of sillucin, a highly knotted, cysteine-rich peptide, by cyanylation/cleavage mass mapping.
-
Pubmed ID
- 11294620
-
Reference
- Biochemistry. 2001 Apr 17;40(15):4531-4538.
-
Author
- Qi J, Wu J, Somkuti GA, Watson JT.