General Information

    • DRAMP ID

    • DRAMP03155

    • Peptide Name

    • Sillucin

    • Source

    • Rhizomucor pusillus

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • ACLPNSCVSKGCCCGBSGYWCRQCGIKYTC

    • Sequence Length

    • 30

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Bridge

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03155 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03155.

Physicochemical Information

    • Formula

    • C126H195N37O37S8

    • Absent Amino Acids

    • DEFHM

    • Common Amino Acids

    • C

    • Mass

    • 3209.31

    • PI

    • 8.52

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 5

    • Net Charge

    • +3

    • Boman Index

    • -19.23

    • Hydrophobicity

    • 0.173

    • Aliphatic Index

    • 39

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 8980

    • Absorbance 280nm

    • 309.66

    • Polar Residues

    • 19

DRAMP03155

DRAMP03155 chydropathy plot

Comments Information

    • Function

    • Sillucin is an antimicrobial agent produced by the thermophilic fungus Rhizomucor pusillus in liquid culture; it is effective against Gram-positive bacteria at the level of RNA metabolism.

    • PTM

    • Contains four disulfide bonds 2-7; 12-24; 13-30; 14-21.

Literature Information

  • ·Literature 1

    • Title

    • The primary structure of sillucin and antimicrobial peptide from Mucor pusillus.

    • Reference

    • FEBS Lett. 1979 Jan 1;97(1):81-83.

    • Author

    • Bradley WA, Somkuti GA.
  • ·Literature 2

    • Title

    • Determination of the disulfide structure of sillucin, a highly knotted, cysteine-rich peptide, by cyanylation/cleavage mass mapping.

    • Reference

    • Biochemistry. 2001 Apr 17;40(15):4531-4538.

    • Author

    • Qi J, Wu J, Somkuti GA, Watson JT.