General Information

    • DRAMP ID

    • DRAMP03157

    • Peptide Name

    • Halocidin subunit B

    • Source

    • Halocynthia aurantium (Sea peach)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • ALLHHGLNCAKGVLA

    • Sequence Length

    • 15

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-positive bacterium: Staphylococcus aureus;
      • Gram-negative bacterium: Pseudomonas aeruginosa.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03157 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03157.

Physicochemical Information

    • Formula

    • C67H113N21O17S

    • Absent Amino Acids

    • DEFIMPQRSTWY

    • Common Amino Acids

    • L

    • Mass

    • 1516.82

    • PI

    • 8.28

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +3

    • Boman Index

    • 10.8

    • Hydrophobicity

    • 0.847

    • Aliphatic Index

    • 143.33

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 4

DRAMP03157

Comments Information

    • Function

    • Has antimicrobial activity, possibly by attacking the bacterial cell membrane.

Literature Information

  • ·Literature 1

    • Title

    • Halocidin: a new antimicrobial peptide from hemocytes of the solitary tunicate, Halocynthia aurantium.

    • Reference

    • FEBS Lett. 2002 Jun 19;521(1-3):81-86.

    • Author

    • Jang WS, Kim KN, Lee YS, Nam MH, Lee IH.