• DRAMP ID

    • DRAMP03188
    • Peptide Name

    • Antibacterial protein LL-37 (primates, mammals, animals)
    • Source

    • Saguinus oedipus (Cotton-top tamarin)
    • Family

    • Belongs to the cathelicidin family
    • Gene

    • CAMP
    • Sequence

    • RLGGILRKAGEKIGGGLKKIGQKIKDFFGKLAPRTES
    • Sequence Length

    • 37
    • Protein Existence

    • Homology
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-
    • Target Organism

      • Gram-negative bacteria: Escherichia coli ML-35, Pseudomonas aeruginosa ATCC 27853, Staphylococcus aureus 710A, Enterococcus faecalis A16.
      • Yeast: Candida albicans clinical isolate.
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Lipopolysaccharide (LPS)-binding
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Bridge
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP03188 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP03188.
    • Formula

    • C179H308N54O47
    • Absent Amino Acids

    • CHMNVWY
    • Common Amino Acids

    • G
    • Mass

    • 3968.75
    • PI

    • 10.71
    • Basic Residues

    • 10
    • Acidic Residues

    • 3
    • Hydrophobic Residues

    • 12
    • Net Charge

    • +7
    • Boman Index

    • -61
    • Hydrophobicity

    • -0.505
    • Aliphatic Index

    • 89.73
    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 10

DRAMP03188

DRAMP03188 chydropathy plot
    • Function

    • Has antibacterial activity (By similarity).
  • ·Literature 1
    • Title

    • Evolution of the primate cathelicidin. Correlation between structural variations and antimicrobial activity.
    • Reference

    • J Biol Chem. 2006 Jul 21;281(29):19861-19871.
    • Author

    • Zelezetsky I, Pontillo A, Puzzi L, Antcheva N, Segat L, Pacor S, Crovella S, Tossi A.