General Information
-
DRAMP ID
- DRAMP03194
-
Peptide Name
- Theta defensin subunit A (primates, mammals, animals)
-
Source
- Papio hamadryas (Hamadryas baboon)
-
Family
- Belongs to the alpha-defensin family (Theta subfamily)
-
Gene
- Not found
-
Sequence
- RCVCTRGFC
-
Sequence Length
- 9
-
UniProt Entry
- P86722
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Antifungal
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Target Organism
- No MICs found in DRAMP database
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP03194.
Physicochemical Information
-
Formula
- C41H69N15O11S3
Absent Amino Acids
- ADEHIKLMNPQSWY
Common Amino Acids
- C
Mass
- 1044.27
PI
- 8.73
Basic Residues
- 2
Acidic Residues
- 0
Hydrophobic Residues
- 2
Net Charge
- +2
-
Boman Index
- -20.61
Hydrophobicity
- 0.489
Aliphatic Index
- 32.22
Half Life
-
- Mammalian:1 hour
- Yeast:2 min
- E.coli:2 min
Extinction Coefficient Cystines
- 125
Absorbance 280nm
- 15.63
Polar Residues
- 5
DRAMP03194
Comments Information
Forms a cyclic peptide with subunit A (PhTD-3) or with subunit B (PhTD-1). An additional intersubunit disulfide bond is formed.
Literature Information
- ·Literature 1
-
Title
- De novo sequencing of two new cyclic theta-defensins from baboon (Papio hamadryas) leukocytes by matrix-assisted laser desorption/ionization mass spectrometry.
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Pubmed ID
- 20155756
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Reference
- Rapid Commun Mass Spectrom. 2010 Mar 15;24(5):599-604.
-
Author
- Stegemann C, Tsvetkova EV, Aleshina GM, Lehrer RI, Kokryakov VN, Hoffmann R.