General Information

    • DRAMP ID

    • DRAMP03196

    • Peptide Name

    • PhTD-1 (PhTD1; primates, mammals, animals)

    • Source

    • Papio hamadryas (Hamadryas baboon)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • RCVCRRGVCRCVCTRGFC

    • Sequence Length

    • 18

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal

    • Target Organism

      • In low salt conditions: Escherichia coli ML35p (MIC=1.5 µM), Listeria monocytogenes EGD (MIC=1.6 µM) and methicillin-resistant Staphylococcus aureus ATCC 33591 (MIC=2.5 µM),.
      • Fungi: Candida albicans 820 (MIC=1.6 µM);
      • At high physiological salt concentrations: Escherichia coli ML35p (MIC=2.0 µM), Listeria monocytogenes EGD (MIC=1.7 µM), Staphylococcus aureus ATCC 33591 (MIC=3.6 µM), Candida albicans 820 (MIC=6.5 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • No specific N-terminal

    • C-terminal Modification

    • No specific C-terminal

    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bonds between Cys2 and Cys11; Cys4 and Cys9; Cys13 and Cys18.

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03196 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03196.

Physicochemical Information

    • Formula

    • C80H141N33O20S6

    • Absent Amino Acids

    • ADEHIKLMNPQSWY

    • Common Amino Acids

    • C

    • Mass

    • 2077.57

    • PI

    • 9.3

    • Basic Residues

    • 5

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 4

    • Net Charge

    • +5

    • Boman Index

    • -52.51

    • Hydrophobicity

    • 0.356

    • Aliphatic Index

    • 48.33

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 375

    • Absorbance 280nm

    • 22.06

    • Polar Residues

    • 9

DRAMP03196

DRAMP03196 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • De novo sequencing of two new cyclic theta-defensins from baboon (Papio hamadryas) leukocytes by matrix-assisted laser desorption/ionization mass spectrometry.

    • Reference

    • Rapid Commun Mass Spectrom. 2010 Mar 15;24(5):599-604.

    • Author

    • Stegemann C, Tsvetkova EV, Aleshina GM, Lehrer RI, Kokryakov VN, Hoffmann R.