• DRAMP ID

    • DRAMP03197
    • Peptide Name

    • PhTD-3 (PhTD3; primates, mammals, animals)
    • Source

    • Papio hamadryas (Hamadryas baboon)
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • RCVCTRGFCRCVCTRGFC
    • Sequence Length

    • 18
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal
    • Target Organism

      • In low salt conditions: Escherichia coli ML35p (MIC=1.7 µM), Listeria monocytogenes EGD (MIC=1.5 µM), Staphylococcus aureus ATCC 33591 (MIC=1.7 µM), Candida albicans 820 (MIC=1.4 µM);
      • At high physiological salt concentrations: Escherichia coli ML35p (MIC=2.2 µM), Listeria monocytogenes EGD (MIC=1.9 µM), Staphylococcus aureus ATCC 33591 (MIC=4.5 µM), Candida albicans 820 (MIC=7.4 µM).
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Cyclic
    • N-terminal Modification

    • No specific N-terminal
    • C-terminal Modification

    • No specific C-terminal
    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bonds between Cys2 and Cys11; Cys4 and Cys9; Cys13 and Cys18.
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP03197 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP03197.
    • Formula

    • C82H136N30O21S6
    • Absent Amino Acids

    • ADEHIKLMNPQSWY
    • Common Amino Acids

    • C
    • Mass

    • 2070.53
    • PI

    • 9.01
    • Basic Residues

    • 4
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 4
    • Net Charge

    • +4
    • Boman Index

    • -41.22
    • Hydrophobicity

    • 0.489
    • Aliphatic Index

    • 32.22
    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 375
    • Absorbance 280nm

    • 22.06
    • Polar Residues

    • 10

DRAMP03197

DRAMP03197 chydropathy plot
    • Comment

    • No comments found on DRAMP database
  • ·Literature 1
    • Title

    • De novo sequencing of two new cyclic theta-defensins from baboon (Papio hamadryas) leukocytes by matrix-assisted laser desorption/ionization mass spectrometry.
    • Reference

    • Rapid Commun Mass Spectrom. 2010 Mar 15;24(5):599-604.
    • Author

    • Stegemann C, Tsvetkova EV, Aleshina GM, Lehrer RI, Kokryakov VN, Hoffmann R.