General Information

    • DRAMP ID

    • DRAMP03199

    • Peptide Name

    • PhD1 (PhD-1; Defensin-1; primates, mammals, animals)

    • Source

    • Papio hamadryas (Hamadryas baboon)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • RRICRCRIGRCLGLEVYFGVCFLHGRLARRCCR

    • Sequence Length

    • 33

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-negative bacterium: Escherichia coli;
      • Gram-positive bacteria: Listeria monocytogenes, Staphylococcus aureus.
      • Yeast: Candida albicans.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03199 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03199.

Physicochemical Information

    • Formula

    • C167H282N62O37S6

    • Absent Amino Acids

    • DKMNPQSTW

    • Common Amino Acids

    • R

    • Mass

    • 3942.83

    • PI

    • 10.6

    • Basic Residues

    • 10

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +9

    • Boman Index

    • -89.08

    • Hydrophobicity

    • 0.149

    • Aliphatic Index

    • 91.52

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 1865

    • Absorbance 280nm

    • 58.28

    • Polar Residues

    • 11

DRAMP03199

DRAMP03199 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • alpha-Defensins from blood leukocytes of the monkey Papio hamadryas.

    • Reference

    • Biochemistry (Mosc). 2006 Aug;71(8):879-883.

    • Author

    • Tsvetkova EV, Aleshina GM, Shamova OV, Leonova LE, Lehrer RI, Kokryakov VN.