General Information

    • DRAMP ID

    • DRAMP03206

    • Peptide Name

    • Theta defensin subunit C (BTD-c; BTD-4 subunit 2; primates, mammals, animals)

    • Source

    • Papio anubis (Olive baboon)

    • Family

    • Belongs to the alpha-defensin family (Theta subfamily)

    • Gene

    • BTDC

    • Sequence

    • RCICLLGIC

    • Sequence Length

    • 9

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03206 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03206.

Physicochemical Information

    • Formula

    • C41H76N12O10S3

    • Absent Amino Acids

    • ADEFHKMNPQSTVWY

    • Common Amino Acids

    • C

    • Mass

    • 993.31

    • PI

    • 7.97

    • Basic Residues

    • 1

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 4

    • Net Charge

    • +1

    • Boman Index

    • 9.54

    • Hydrophobicity

    • 2.133

    • Aliphatic Index

    • 173.33

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 15.63

    • Polar Residues

    • 4

DRAMP03206

Comments Information

    • Forms a cyclic peptide with subunit A (BTD-4). An additional intersubunit disulfide bond is formed.

Literature Information

  • ·Literature 1

    • Title

    • Isolation, synthesis, and antimicrobial activities of naturally occurring theta-defensin isoforms from baboon leukocytes.

    • Reference

    • Infect Immun. 2008 Dec;76(12):5883-5891.

    • Author

    • Garcia AE, Osapay G, Tran PA, Yuan J, Selsted ME.