• DRAMP ID

    • DRAMP03212
    • Peptide Name

    • BTD-7 (theta-defensin; primates, mammals, animals)
    • Source

    • Papio anubis (Olive baboon)
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • RCVCTRGFCRCFCRRGVC
    • Sequence Length

    • 18
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
    • Target Organism

      • Gram-positive bacterium: Staphylococcus aureus 502a;
      • Gram-negative bacterium: Escherichia coli ML35.
      • Fungi: Candida albicans 16820.
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Cell membrane
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP03212 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP03212.
    • Formula

    • C84H141N33O20S6
    • Absent Amino Acids

    • ADEHIKLMNPQSWY
    • Common Amino Acids

    • C
    • Mass

    • 2125.61
    • PI

    • 9.3
    • Basic Residues

    • 5
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 4
    • Net Charge

    • +5
    • Boman Index

    • -53.57
    • Hydrophobicity

    • 0.278
    • Aliphatic Index

    • 32.22
    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 375
    • Absorbance 280nm

    • 22.06
    • Polar Residues

    • 9

DRAMP03212

DRAMP03212 chydropathy plot
    • Function

    • BTD-7 has antimicrobial activity against the Gram-negative bacterium E. coli ML35 and the Gram-positive bacterium S. aureus 502a, and the fungus C. albicans 16820.
  • ·Literature 1
    • Title

    • Isolation, synthesis, and antimicrobial activities of naturally occurring theta-defensin isoforms from baboon leukocytes.
    • Reference

    • Infect Immun. 2008 Dec;76(12):5883-5891.
    • Author

    • Garcia AE, Osapay G, Tran PA, Yuan J, Selsted ME.