General Information
-
DRAMP ID
- DRAMP03241
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Peptide Name
- M-zodatoxin-Lt8f (M-ZDTX-Lt8f; Cytoinsectotoxin-1f, CIT-1f; spiders, Arthropods, animals)
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Source
- Lachesana tarabaevi (Spider)
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Family
- Belongs to the cytoinsectotoxin family
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Gene
- cit 1-7
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Sequence
- GFFGNTWKKIKGKADKIMLKKAVKIMVKKEGISKEEAQAKVDAMSKKQIRLYLLKHYGKKALQKASEKL
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Sequence Length
- 69
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Protein Existence
- Protein level
Activity Information
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Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram-, Insecticidal
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Target Organism
-
- Gram-negative bacterium: Escherichia coli.
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
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Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP03241.
Physicochemical Information
-
Formula
- C360H610N98O92S3
Absent Amino Acids
- CP
Common Amino Acids
- K
Mass
- 7879.59
PI
- 10.21
Basic Residues
- 21
Acidic Residues
- 6
Hydrophobic Residues
- 24
Net Charge
- +15
-
Boman Index
- -107.07
Hydrophobicity
- -0.632
Aliphatic Index
- 84.93
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 8480
Absorbance 280nm
- 124.71
Polar Residues
- 12
DRAMP03241
Comments Information
Function
- Insecticidal, cytolytic and antimicrobial peptide. Has insecticidal activity against the flesh fly S. carnaria. Has antibacterial activity against the Gram-negative bacteria E.coli. Forms voltage-dependent, ion-permeable channels in membranes. At high concentration causes cell membrane lysis.
Tissue specificity
- Expressed by the venom gland.
Literature Information
- ·Literature 1
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Title
- Cyto-insectotoxins, a novel class of cytolytic and insecticidal peptides from spider venom.
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Pubmed ID
- 18215128
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Reference
- Biochem J. 2008 May 1;411(3):687-696.
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Author
- Vassilevski A.A, Kozlov S.A, Samsonova O.V, Egorova N.S, Karpunin D.V, Pluzhnikov K.A, Feofanov A.V, Grishin E.V.