General Information

    • DRAMP ID

    • DRAMP03252

    • Peptide Name

    • M-lycotoxin-Ls2a (M-LCTX-Ls2a; Lycocitin-3; spiders, Arthropods, animals)

    • Source

    • Lycosa singoriensis (Wolf spider) (Aranea singoriensis)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • KIKWFKTMKSLAKFLAKEQMKKHLGE

    • Sequence Length

    • 26

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Antifungal

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Cell membrane

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03252 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03252.

Physicochemical Information

    • Formula

    • C147H242N38O34S2

    • Absent Amino Acids

    • CDNPRVY

    • Common Amino Acids

    • K

    • Mass

    • 3149.89

    • PI

    • 10.22

    • Basic Residues

    • 9

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +7

    • Boman Index

    • -36.96

    • Hydrophobicity

    • -0.723

    • Aliphatic Index

    • 67.69

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 220

    • Polar Residues

    • 3

DRAMP03252

DRAMP03252 chydropathy plot

Comments Information

    • Function

    • Forms pore that permeabilize the cell membrane. Promotes efflux of calcium from synaptosomes, causes hemolysis, and dissipates voltage gradients across muscle membrane. Potently inhibits the growth of bacteria and yeast. May Function

Literature Information

  • ·Literature 1

    • Title

    • De novo sequencing of antimicrobial peptides isolated from the venom glands of the wolf spider Lycosa singoriensis.

    • Reference

    • J Mass Spectrom. 2004 Feb;39(2):193-201.

    • Author

    • Budnik BA, Olsen JV, Egorov TA, Anisimova VE, Galkina TG, Musolyamov AK, Grishin EV, Zubarev RA.