• DRAMP ID

    • DRAMP03254
    • Peptide Name

    • M-lycotoxin-Ls3b (M-LCTX-Ls3b; Lycocitin-2; spiders, Arthropods, animals)
    • Source

    • Lycosa singoriensis (Wolf spider) (Aranea singoriensis)
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • GRLQAFLAKMKEIAAQTL
    • Sequence Length

    • 18
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus 209P, Bacillus subtilis ATCC 6633 (MIC=1.57-3.14 µM);
      • Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=3.14-6.29 µM), Pseudomonas aeruginosa ATCC 27853 (MIC=5.02-10.05 µM).
      • Fungi: Candida albicans.
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Linear
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Amidation
    • Nonterminal Modifications and Unusual Amino Acids

    • Free
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP03254 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP03254.
    • Formula

    • C89H153N25O24S
    • Absent Amino Acids

    • CDHNPSVWY
    • Common Amino Acids

    • A
    • Mass

    • 1989.41
    • PI

    • 9.99
    • Basic Residues

    • 3
    • Acidic Residues

    • 1
    • Hydrophobic Residues

    • 9
    • Net Charge

    • +2
    • Boman Index

    • -13.29
    • Hydrophobicity

    • 0.217
    • Aliphatic Index

    • 108.89
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 2

DRAMP03254

DRAMP03254 chydropathy plot
    • Function

    • Inhibits growth of Gram-positive and Gram-negative bacteria and fungi.
    • Tissue specificity

    • Expressed by the venom gland.
    • PTM

    • C-terminal amidation.
  • ·Literature 1
    • Title

    • De novo sequencing of antimicrobial peptides isolated from the venom glands of the wolf spider Lycosa singoriensis.
    • Reference

    • J Mass Spectrom. 2004 Feb;39(2):193-201.
    • Author

    • Budnik BA, Olsen JV, Egorov TA, Anisimova VE, Galkina TG, Musolyamov AK, Grishin EV, Zubarev RA.