General Information

    • DRAMP ID

    • DRAMP03281

    • Peptide Name

    • Turkey Heterophil Peptide 3 (Antimicrobial peptide THP3; Birds, animals)

    • Source

    • Meleagris gallopavo (Common turkey)

    • Family

    • Belongs to the beta-defensin family

    • Gene

    • Not found

    • Sequence

    • LSCKRGTCHFGRCPSHLIKGSCSGG

    • Sequence Length

    • 25

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacterium: Staphylococcus aureus.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Bridge

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03281 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03281.

Physicochemical Information

    • Formula

    • C106H175N37O31S4

    • Absent Amino Acids

    • ADEMNQVWY

    • Common Amino Acids

    • G

    • Mass

    • 2592.02

    • PI

    • 9.31

    • Basic Residues

    • 6

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 4

    • Net Charge

    • +6

    • Boman Index

    • -38.87

    • Hydrophobicity

    • -0.232

    • Aliphatic Index

    • 46.8

    • Half Life

      • Mammalian:5.5 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 250

    • Absorbance 280nm

    • 10.42

    • Polar Residues

    • 14

DRAMP03281

DRAMP03281 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Isolation of antimicrobial peptides from avian heterophils.

    • Reference

    • J Leukoc Biol. 1994 Nov;56(5):661-665.

    • Author

    • Evans EW, Beach GG, Wunderlich J, Harmon BG.