General Information
-
DRAMP ID
- DRAMP03287
-
Peptide Name
- Ostricacin-3 (Beta-defensin 7; Birds, animals)
-
Source
- Struthio camelus (Ostrich)
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Family
- Belongs to the beta-defensin family
-
Gene
- Not found
-
Sequence
- IPRPLDPCIAQNGRCFTGICRYPYFWIGTCRNGKSCCRRR
-
Sequence Length
- 40
-
UniProt Entry
- P85115
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Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
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Target Organism
-
- Gram-positive bacterium: Staphylococcus aureus 1056-MRSA (MIC=2.78 µg/ml);
- Gram-negative bacterium: Escherichia coli O157:H7 (MIC=2.41 µg/ml).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Cyclic
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N-terminal Modification
- Free
-
C-terminal Modification
- Free
-
Nonterminal Modifications and Unusual Amino Acids
- Disulfide bonds between Cys8 and Cys36,Cys15 and Cys30,Cys20 and Cys37.
-
Stereochemistry
- L
-
Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- Please click DRAMP03287_predicted_structure.pdb to download.
Physicochemical Information
-
Formula
- C202H318N66O51S6
Absent Amino Acids
- EHMV
Common Amino Acids
- R
Mass
- 4679.52
PI
- 9.69
Basic Residues
- 8
Acidic Residues
- 1
Hydrophobic Residues
- 9
Net Charge
- +7
-
Boman Index
- -100.21
Hydrophobicity
- -0.473
Aliphatic Index
- 51.25
Half Life
-
- Mammalian:20 hour
- Yeast:30 min
- E.coli:>10 hour
Extinction Coefficient Cystines
- 8855
Absorbance 280nm
- 227.05
Polar Residues
- 17
DRAMP03287
Comments Information
PTM
- Contains three disulfide bonds 8-36; 15-30; 20-37.
Literature Information
- ·Literature 1
-
Title
- Identification of three novel ostricacins: an update on the phylogenetic perspective of beta-defensins.
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Pubmed ID
- 16459058
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Reference
- Int J Antimicrob Agents. 2006 Mar;27(3):229-235.
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Author
- Sugiarto H, Yu PL.