General Information
-
DRAMP ID
- DRAMP03295
-
Peptide Name
- Defensin-B4 (DefB4; OaDefB4; mammals, animals)
-
Source
- Ornithorhynchus anatinus (Duckbill platypus)
-
Family
- Belongs to the beta-defensin family
-
Gene
- Not found
-
Sequence
- CKGKLGYCRSKCQSKQVELGKCSTKAICCGISTGTSSSQGSHEVPVINSEPALESKPEPQDTQEEEATMVSE
-
Sequence Length
- 72
-
UniProt Entry
- P0C8A8
-
Protein Existence
- Transcript level
Activity Information
-
Biological Activity
- Antimicrobial
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
-
Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP03295.
Physicochemical Information
-
Formula
- C314H520N90O116S7
Absent Amino Acids
- FW
Common Amino Acids
- S
Mass
- 7636.54
PI
- 5.3
Basic Residues
- 9
Acidic Residues
- 10
Hydrophobic Residues
- 13
Net Charge
- -1
-
Boman Index
- -146.39
Hydrophobicity
- -0.686
Aliphatic Index
- 52.78
Half Life
-
- Mammalian:1.2 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 1865
Absorbance 280nm
- 26.27
Polar Residues
- 30
DRAMP03295
![DRAMP03295 chydropathy plot](http://dramp.cpu-bioinfor.org/tmp/all_info_png/pepwindow_DRAMP03295.1.png)
Comments Information
Function
- Has antimicrobial activity (By similarity).
Tissue specificity
- Highly expressed in kidney, lowly expressed in spleen, and expressed at lower levels in lung.
PTM
- Contains three disulfide bonds (By similarity).
Literature Information
- ·Literature 1
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Title
- Defensins and the convergent evolution of platypus and reptile venom genes.
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Pubmed ID
- 18463304
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Reference
- Genome Res. 2008 Jun;18(6):986-994.
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Author
- Whittington CM, Papenfuss AT, Bansal P, Torres AM, Wong ES, Deakin JE, Graves T, Alsop A, Schatzkamer K, Kremitzki C, Ponting CP, Temple-Smith P, Warren WC, Kuchel PW, Belov K.
- ·Literature 2
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Title
- Expression patterns of platypus defensin and related venom genes across a range of tissue types reveal the possibility of broader functions for OvDLPs than previously suspected.
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Pubmed ID
- 18662710
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Reference
- Toxicon. 2008 Sep 15;52(4):559-565.
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Author
- Whittington CM, Papenfuss AT, Kuchel PW, Belov K.