General Information
-
DRAMP ID
- DRAMP03298
-
Peptide Name
- Defensin-A1 (DefA1; OaDefA1; mammals, animals)
-
Source
- Ornithorhynchus anatinus (Duckbill platypus)
-
Family
- Belongs to the alpha-defensin family
-
Gene
- Not found
-
Sequence
- DTTFCRCRVSCNILEKYSGKCELSGRTARICC
-
Sequence Length
- 32
-
UniProt Entry
- P0C8A1
-
Protein Existence
- Transcript level
Activity Information
-
Biological Activity
- Antimicrobial
-
Target Organism
- No MICs found in DRAMP database
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP03298.
Physicochemical Information
-
Formula
- C147H247N47O47S6
Absent Amino Acids
- HMPQW
Common Amino Acids
- C
Mass
- 3617.22
PI
- 8.67
Basic Residues
- 6
Acidic Residues
- 3
Hydrophobic Residues
- 7
Net Charge
- +3
-
Boman Index
- -79.74
Hydrophobicity
- -0.188
Aliphatic Index
- 60.94
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:>10 hour
Extinction Coefficient Cystines
- 1865
Absorbance 280nm
- 60.16
Polar Residues
- 16
DRAMP03298
Comments Information
Function
- Has antimicrobial activity (By similarity).
Tissue specificity
- Highly expressed in intestine, expressed at lower levels in spleen, and at very low levels in kidney and lung.
PTM
- Contains three disulfide bonds (By similarity).
Literature Information
- ·Literature 1
-
Title
- Defensins and the convergent evolution of platypus and reptile venom genes.
-
Pubmed ID
- 18463304
-
Reference
- Genome Res. 2008 Jun;18(6):986-994.
-
Author
- Whittington CM, Papenfuss AT, Bansal P, Torres AM, Wong ES, Deakin JE, Graves T, Alsop A, Schatzkamer K, Kremitzki C, Ponting CP, Temple-Smith P, Warren WC, Kuchel PW, Belov K.
- ·Literature 2
-
Title
- Expression patterns of platypus defensin and related venom genes across a range of tissue types reveal the possibility of broader functions for OvDLPs than previously suspected.
-
Pubmed ID
- 18662710
-
Reference
- Toxicon. 2008 Sep 15;52(4):559-565.
-
Author
- Whittington CM, Papenfuss AT, Kuchel PW, Belov K.