General Information
-
DRAMP ID
- DRAMP03303
-
Peptide Name
- Theromyzin (Frogs, amphibians, animals)
-
Source
- Theromyzon tessulatum (Duck leech)
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- DHHHDHGHDDHEHEELTLEKIKEKIKDYADKTPVDQLTERVQAGRDYLLGKGARPSHLPARVDRHLSKLTAAEKQELADYLLTFLH
-
Sequence Length
- 86
-
UniProt Entry
- Q6T6C1
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+
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Target Organism
-
- Gram-positive bacterium: Micrococcus luteus.
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP03303.
Physicochemical Information
-
Formula
- C438H688N132O136
Absent Amino Acids
- CMNW
Common Amino Acids
- L
Mass
- 9979.08
PI
- 6.03
Basic Residues
- 23
Acidic Residues
- 18
Hydrophobic Residues
- 25
Net Charge
- +5
-
Boman Index
- -243.56
Hydrophobicity
- -1.07
Aliphatic Index
- 81.74
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:>10 hour
Extinction Coefficient Cystines
- 4470
Absorbance 280nm
- 52.59
Polar Residues
- 14
DRAMP03303
Comments Information
Comment
- No comments found on DRAMP database
Literature Information
- ·Literature 1
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Title
- Molecular characterization of two novel antibacterial peptides inducible upon bacterial challenge in an annelid, the leech Theromyzon tessulatum.
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Pubmed ID
- 15102860
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Reference
- J Biol Chem. 2004 Jul 23;279(30):30973-30982.
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Author
- Tasiemski A, Vandenbulcke F, Mitta G, Lemoine J, Lefebvre C, Sautière PE, Salzet M.