General Information

    • DRAMP ID

    • DRAMP03312

    • Peptide Name

    • Metalnikowin-1 (Metalnikowin I; Insects, animals)

    • Source

    • Palomena prasina (Green shield bug) (Cimex prasinus)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • VDKPDYRPRPRPPNM

    • Sequence Length

    • 15

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-

    • Target Organism

      • Gram-negative bacteria: Escherichia coli D22 (MIC=50-100 µM), Salmonella typhimurium (MIC=50-100 µM), Alcaligenes faecalis (MIC=50-100 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Rich

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03312 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03312.

Physicochemical Information

    • Formula

    • C80H128N26O22S

    • Absent Amino Acids

    • ACEFGHILQSTW

    • Common Amino Acids

    • P

    • Mass

    • 1838.12

    • PI

    • 9.98

    • Basic Residues

    • 4

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 1

    • Net Charge

    • +2

    • Boman Index

    • -68.14

    • Hydrophobicity

    • -2.073

    • Aliphatic Index

    • 19.33

    • Half Life

      • Mammalian:100 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 106.43

    • Polar Residues

    • 2

DRAMP03312

Comments Information

    • Function

    • Antibacterial peptide active against Gram-negative bacteria.

    • Induction

    • By bacterial infection.

Literature Information

  • ·Literature 1

    • Title

    • The inducible antibacterial peptides of the hemipteran insect Palomena prasina: identification of a unique family of proline-rich peptides and of a novel insect defensin.

    • Reference

    • J. Insect Physiol. 1996; 42: 81-89.

    • Author

    • Chernysh S, Cociancich S, Briand JP, Hetru C, Bulet P.