General Information

    • DRAMP ID

    • DRAMP03333

    • Peptide Name

    • Alpha-defensin cryptdin-5 (Defensin-related cryptdin5; Rodents, mammals, animals)

    • Source

    • Mus musculus (Mouse)

    • Family

    • Belongs to the alpha-defensin family

    • Gene

    • Defa5

    • Sequence

    • SKKLICYCRIRGCKRRERVFGTCRNLFLTFVFCCS

    • Sequence Length

    • 35

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-positive bacterium: Listeria monocytogenes EGD;
      • Gram-negative bacteria: Escherichia coli ML-35p, mouse-avirulent Salmonella typhimurium 7953.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bonds between Cys6 and Cys34,Cys8 and Cys23,Cys13 and Cys33.

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03333 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03333.

Physicochemical Information

    • Formula

    • C184H301N57O44S6

    • Absent Amino Acids

    • ADHMPQW

    • Common Amino Acids

    • CR

    • Mass

    • 4208.13

    • PI

    • 9.86

    • Basic Residues

    • 9

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +8

    • Boman Index

    • -77.54

    • Hydrophobicity

    • 0.12

    • Aliphatic Index

    • 72.29

    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1865

    • Absorbance 280nm

    • 54.85

    • Polar Residues

    • 14

DRAMP03333

DRAMP03333 chydropathy plot

Comments Information

    • Function

    • Probably contributes to the antimicrobial barrier Function

    • PTM

    • Contains three disulfide bonds.

Literature Information

  • ·Literature 1

    • Title

    • Enteric defensins: antibiotic peptide components of intestinal host defense.

    • Reference

    • J Cell Biol. 1992 Aug;118(4):929-936.

    • Author

    • Selsted ME, Miller SI, Henschen AH, Ouellette AJ.