General Information

    • DRAMP ID

    • DRAMP03343

    • Peptide Name

    • Alpha-defensin cryptdin-16 (Defensin-related cryptdin-16; Rodents, mammals, animals)

    • Source

    • Mus musculus (Mouse)

    • Family

    • Belongs to the alpha-defensin family

    • Gene

    • Defa16

    • Sequence

    • LRDLVCYCRSRGCKGRERMNGTCRKGHLMYTLCCR

    • Sequence Length

    • 35

    • Protein Existence

    • Transcript level

Activity Information

    • Biological Activity

    • Antimicrobial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bonds between Cys6 and Cys34,Cys8 and Cys23,Cys13 and Cys33.

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP03343 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP03343.

Physicochemical Information

    • Formula

    • C167H285N61O46S8

    • Absent Amino Acids

    • AFIPQW

    • Common Amino Acids

    • R

    • Mass

    • 4139.96

    • PI

    • 9.61

    • Basic Residues

    • 10

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 5

    • Net Charge

    • +8

    • Boman Index

    • -111.33

    • Hydrophobicity

    • -0.606

    • Aliphatic Index

    • 52.86

    • Half Life

      • Mammalian:5.5 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 3355

    • Absorbance 280nm

    • 98.68

    • Polar Residues

    • 16

DRAMP03343

DRAMP03343 chydropathy plot

Comments Information

    • Function

    • Probably contributes to the antimicrobial barrier Function

    • Tissue specificity

    • Paneth cells of the small bowel.

    • PTM

    • Contains three disulfide bonds (By similarity).

Literature Information

  • ·Literature 1

    • Title

    • Mouse Paneth cell defensins: primary structures and antibacterial activities of numerous cryptdin isoforms.

    • Reference

    • Genomics. 1994;19:448-453.

    • Author

    • Ouellette AJ, Hsieh MM, Nosek MT, Cano-Gauci DF, Huttner KM, Buick RN, Selsted ME.
  • ·Literature 2

    • Title

    • Structure and diversity of the murine cryptdin gene family.

    • Reference

    • Infect Immun. 1994 Nov;62(11):5040-5047.

    • Author

    • Huttner KM, Selsted ME, Ouellette AJ.